Creatinine clearance formula

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The Cockcroft and Gault formula (CG) was developed in 1973 using data from 249 men with creatinine clearance (CCr) from approximately 30 to 130 mL/m2. It is not adjusted for body surface area. CG is no longer recommended for use because it has not been expressed using standardized creatinine values. Calculator Calculate Results The Cockcroft and Gault formula (1973) milliliters per minute Additional information The Cockcroft and Gault formula (1973) C Cr=x 0.85 (if female) Abbreviations/ Units C Cr (creatinine clearance) = mL/minute Age = years Weight = kg SCr (serum creatinine) = mg/dL Why is the Cockcroft-Gault formula provided on this website? • The Cockcroft-Gault (CG) formula is provided on this website for research purposes only. It should not be used for drug dosing or to estimate GFR. • The best way to determine drug dosing is with the CKD-EPI Creatinine Equation (2009) or the MDRD Study. Both have been shown to be more accurate than the CG formula. Why isn’t the Cockcroft-Gault formula recommended for clinical use? • The Cockcroft-Gault (CG) formula has not been expressed using standardized creatinine values. This means it will give inaccurate results. It is not recommended for clinical use. • Creatinine assays are standardized to reference methods. Both the MDRD Study and CKD-EPI have been expressed for these reference methods, but the Cockcroft-Gault formula has not. The assay used to develop the Cockcroft-Gault was likely 10-20% higher than current methods, the...

Theresa Hahn, Song Yao, Lauren M.Dunford, Julie Thomas, James Lohr, Pradeep Arora, Minoo Battiwalla, Shannon L. Smiley, Philip L. McCarthyJr. “A Comparison of Measured Creatinine Clearance versus Calculated Glomerular Filtration Rate for Assessment of Renal Function before Autologous and Allogeneic BMT“ Biology of Blood and Marrow Transplantation (May 2009) Mary A Winter, Kelly N Guhr, Gina M Berg “Impact of various body weights and serum creatinine concentrations on the bias and accuracy of the Cockcroft-Gault equation“ Pharmacotherapy (May 2012) Daniel L. Brown, Andrew J. Masselink, Christina D. Lalla “Functional Range of Creatinine Clearance for Renal Drug Dosing: A Practical Solution to the Controversy of Which Weight to Use in the Cockcroft-Gault Equation“ Annals of Pharmacotherapy (June 2013) The creatinine clearance calculator finds the creatinine clearance (CrCl), which is an estimate of the Cockcroft-Gault equation. In the article, you can learn how the estimated CrCl calculation is conducted and how to find it directly using urine creatinine concentration. We are also presenting a step-by-step solution to help you understand how to calculate creatinine clearance. We try our best to make our Omni Calculators as precise and reliable as possible. However, this tool can never replace a professional doctor's assessment. If any health condition bothers you, consult a physician. Creatinine clearance, or CrCl for short, is a measure of renal function. Kidneys play a sign...

Overview What is the creatinine clearance test? The creatinine clearance test is an older test used to check your kidney function. This test allows your healthcare provider to look at samples of your urine and blood to see how much of the waste product — creatinine — is filtered out by your kidneys. Abnormal levels of creatinine in your urine and blood could point to an issue like kidney disease. Done in two parts, the creatinine clearance test involves collecting your urine over a 24-hour period of time and then having your blood drawn. These samples are then tested to see how much creatinine was filtered through your kidneys over the 24-hour window. The results of the test will be used in a mathematic formula that figures out your creatinine clearance. Creatinine clearance is one way to estimate your glomerular filtration rate (GFR), or how well the kidneys are filtering your blood. The GFR is the main number used by your provider to determine how well your kidneys are working. The creatinine clearance test is not used very often any more. It has largely been replaced by the estimated GFR (eGFR) equations using creatinine levels in the blood — which means a 24-hour urine collection is not needed. What is creatinine? Creatinine is actually a waste product of creatine. Creatine is a chemical that your body uses to supply your muscles with energy. As you muscles use energy the tissue that makes up your muscles breaks down. This natural breakdown of muscle tissue causes crea...